IODINE-CONTAINING COMPOUNDS OF EXTRATHYROIDAL TISSUES*

Iodine-containing Compounds of Extrathyroidal Tissues.

Phosphorus compounds in animal tissues; the distribution of nucleic acids and other phosphorus-containing compounds in normal and malignant tissues.

Malignant tissues are distinguished from other types of tissues by their capacity for relatively unlimited and uncontrolled growth in the organism. The reason why neoplastic tissues grow continually, in contrast to embryonic tissues which grow only up to a certain point before they begin to differentiate, is a fundamental problem of cancer research. A study of the synthetic mechanisms of the ce...

Factors affecting the extraction of intact ribonucleic Acid from plant tissues containing interfering phenolic compounds.

Using conventional methods it is impossible to extract RNA as uncomplexed intact molecules from the leaves of grapevines (Vitis vinifera L.) and from a number of woody perennial species that contain high levels of reactive phenolic compounds. A procedure involving the use of high concentrations of the chaotropic agent sodium perchlorate prevents the binding of phenolic compounds to RNA during e...

Determination of organic iodine compounds in serum. II. Chromatographic studies of exogenous organic iodine compounds affecting the PBI and BEI.

R1_ values of organic iodine compounds which interfere with the determination of serum protein-bound iodine (P81) and butanol-extractable iodine (BEI) levels were obtained for the solvent system 2-butanol-4% NH4OH (3:1) utilizing descending paper chromatography. The feasibility of employing this system for identification of exogenous organic iodine in patients’ sera was investigated. In general...

Deiodination activity in extrathyroidal tissues of the atlantic hagfish, Myxine glutinosa.

We measured low substrate (<1 nM) thyroid hormone (TH) deiodination activities in liver, muscle, intestine, and brain microsomes of Atlantic hagfish fasted for 2 weeks and found extremely low thyroxine (T(4)) outer-ring deiodination (T(4)ORD) and inner-ring deiodination (T(4)IRD) as well as 3,5,3'-triiodothyronine (T(3)) IRD activities. T(3)ORD, 3',5'-triiodothyronine (rT(3)) ORD and rT(3)IRD a...